Article

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

2020-12-18

Abstract excerpt

<h4>Introductory paragraph</h4> The clinical success of targeted cancer therapy is limited by drug resistance that renders cancers lethal in patients 1-4 . Human tumours can evolve therapy resistance by acquiring de novo genetic alterations and increased heterogeneity via mechanisms that remain incompletely understood 1 . Here, through parallel analysis of human clinical samples, tumour xenograft and cell line...

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Literature Corpus work: 44b756bd-c7e8-5740-8ffb-5b84e4f9e4d5
DOI: 10.1101/2020.12.18.423280

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