Article

Human cancer genomes harbor the mutational signature of tobacco-specific nitrosamines NNN and NNK

2024-06-28

Abstract excerpt

<h4>ABSTRACT</h4> Tobacco usage is linked to multiple cancer types and accounts for a quarter of all cancer-related deaths. Tobacco smoke contains various carcinogenic compounds, including polycyclic aromatic hydrocarbons (PAH), though the mutagenic potential of many tobacco-related chemicals remains largely unexplored. In particular, the highly carcinogenic tobacco-specific nitrosamines NNN and NNK form pre-muta...

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Literature Corpus work: e98f0a7b-f45d-569f-87e2-1a020b600a78
DOI: 10.1101/2024.06.28.600253

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