Article

Single-cell X-chromosome inactivation analysis links biased chimerism to differential gene expression and epigenetic erosion

2024-08-30

Abstract excerpt

Female cells randomly inactivate one X-chromosome, resulting in cellular mosaicism. Determining the bias in X-chromosomal inactivation (XCI) at single cell level may be relevant for understanding diseases prevalent in females. Here, we introduce a computational method that determines XCI profiles at single-cell level using solely sc/snRNA-Seq data. XCI analysis of skin cells from hybrid mice validates our approach...

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Literature Corpus work: 77fac154-233e-5333-98bd-3ecddb36b2f9
DOI: 10.1101/2024.08.29.610317

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