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Article

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

25 Aug 2015

Abstract excerpt

BACKGROUND: APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. METHODS: APC prognostic value was evaluated in 746 stage I-IV CRC patients, stratifying for tumour location and microsatellite instability (MSI). Microarrays were used to identify a gene signature that could classify APC mutation status, and classifier ability to predict prognosis was...

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PMID: 26305864
DOI: 10.1038/bjc.2015.296

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