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Lack ofAPCsomatic mutation is associated with early-onset colorectal cancer in African Americans

11 Sept 2018

Abstract excerpt

African Americans (AAs) have higher incidence and mortality rates of colorectal cancer (CRC) compared with other US populations. They present with more right-sided, microsatellite stable disease and are diagnosed at earlier ages compared with non-Hispanic Whites (NHWs). To gain insight into these trends, we conducted exome sequencing (n = 45), copy number (n = 33) and methylation analysis (n = 11) of...

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PMID: 30239619
DOI: 10.1093/carcin/bgy122

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