Article
Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability.
Genes, chromosomes & cancer - 1 Aug 2010
Albuquerque Cristina, Baltazar Célia, Filipe Bruno, Penha Filipa, Pereira Teresa, Smits Ron, Cravo Marília, Lage Pedro, Fidalgo Paulo, Claro Isabel, Rodrigues Paula, Veiga Isabel, Ramos José Silva, Fonseca Isabel, Leitão Carlos Nobre, Fodde Riccardo
Abstract excerpt
It is unclear whether the mutation spectra in WNT genes vary among distinct types of colorectal tumors. We have analyzed mutations in specific WNT genes in a cohort of 52 colorectal tumors and performed a meta-analysis of previous studies. Notably, significant differences were found among the mut...
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