Article
Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.
Oncogene - 26 Sept 2013
Christie M, Jorissen R N, Mouradov D, Sakthianandeswaren A, Li S, Day F, Tsui C, Lipton L, Desai J, Jones I T, McLaughlin S, Ward R L, Hawkins N J, Ruszkiewicz A R, Moore J, Burgess A W, Busam D, Zhao Q, Strausberg R L, Simpson A J, Tomlinson I P M, Gibbs P, Sieber O M
Abstract excerpt
Biallelic protein-truncating mutations in the adenomatous polyposis coli (APC) gene are prevalent in sporadic colorectal cancer (CRC). Mutations may not be fully inactivating, instead producing WNT/β-catenin signalling levels 'just-right' for tumourigenesis. However, the spectrum of optimal APC genotypes accounting for both hits, and the influence of clinicopathological features on genotype selection remain...
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