Article

A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic Malignancies

2023-10-25

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic activation of MYC in cancers predominantly involves increased transcription rather than coding region mutations. However, MYC-dependent lymphomas frequently contain point mutations in the MYC phospho-degron, including at threonine-58 (T58), where phosphorylation permits binding by the FBW7 ubiquitin ligase triggering MYC degradation. To understand how T58 phosphorylation functions in n...

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Literature Corpus work: 7730ebde-02be-5514-98ac-09c2b11085a3
DOI: 10.1101/2023.10.23.563660

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