Article

Phenotype-dependent subtyping exposes high MYC activity as a targetable dependency in LuAd

2026-05-01

Abstract excerpt

Although 30-40% of human Non-Small Cell lung cancers show low level amplification of c-MYC and genetic evidence supports c-Myc as a key downstream effector of KRas-driven tumourigenesis in mouse models, the functional contribution of MYC to human lung cancer remains unclear. We applied a phenotype-based classifier to the TCGA Lung Adenocarcinoma (LuAd) cohort and found that high MYC transcriptional activity identi...

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Literature Corpus work: 0094cc79-7d4d-5e93-b4b1-afc936c2cce4
DOI: 10.64898/2026.04.27.721038

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