Article
Mice deficient of <i>Myc</i> super-enhancer region reveal a differential control mechanism between normal and pathological growth
2016-10-24
Abstract excerpt
The gene desert upstream of the Myc oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer, including cancers of breast, prostate, and colon. The region shows high conservation between human and mouse and contains multiple MYC enhancers that are activated in tumor cells. However, the role of this region in normal development has not been addressed. Here we show that a 53...
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Identifiers and source
- Literature Corpus work
- 11ea4ba2-f753-53be-ae8a-2fa81ef10e20
- DOI
- 10.1101/082602