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Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation

22 Jul 2023

Abstract excerpt

mice are healthier and longer-lived than control mice, the long-term ramifications of more complete Myc loss remain unknown. We now describe the chronic consequences of body-wide Myc inactivation initiated postnatally. "MycKO" mice acquire numerous features of premature aging, including altered body composition and habitus, metabolic dysfunction, hepatic steatosis, and dysregulation of gene sets involved in...

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PMID: 37481724
DOI: 10.1016/j.celrep.2023.112830

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