Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas.

Oncotarget - 29 Dec 2015

Snijders Antoine M, Liu Yueyong, Su Li, Huang Yurong, Mao Jian-Hua

Abstract excerpt

The tumor suppressor gene FBXW7 is deleted and mutated in many different types of human cancers. FBXW7 primarily exerts its tumor suppressor activity by ubiquitinating different oncoproteins including mTOR. Here we used gene transcript profiling to gain a deeper understanding of the role of FBXW7 in tumor development and to determine the influence of mTOR inhibition by rapamycin on tumor transcriptome and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol
Share to F-Box Proteins
Share to F-Box-WD Repeat-Containing Protein 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma

Share to Neoplasms, Radiation-Induced

Share to Sirolimus

Share to Thymus Neoplasms

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 26575021
DOI: 10.18632/oncotarget.6328
PMCID: PMC4792592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas.PMID 26575021Read ↗

Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development.Semantic proximity Read ↗

Clinical significance of FBXW7 loss of function in human cancersSemantic proximity Read ↗

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.Semantic proximity Read ↗

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Semantic proximity Read ↗

Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligaseSemantic proximity Read ↗

Tumor suppressor functions of FBW7 in cancer development and progressionSemantic proximity Read ↗

Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.Semantic proximity Read ↗

FBXW7: a critical tumor suppressor of human cancers.Semantic proximity Read ↗

FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective StrategiesSemantic proximity Read ↗

Activation of Notch1 drives the development of radiation-induced thymic lymphoma in p53 wild-type miceSemantic proximity Read ↗

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development.Semantic proximity Read ↗

Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.