Article
Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis.
Cell death and differentiation - 1 Jul 2013
Hanel W, Marchenko N, Xu S, Yu S Xiaofeng, Weng W, Moll U
Abstract excerpt
Mutant p53 proteins not only lose their tumor-suppressor function but some acquire oncogenic gain of function (GOF). The published mutp53 knock-in (KI) alleles (R172H, R270H, R248W) manifest GOF by broader tumor spectrum and more metastasis compared with the p53-null allele, but do not shorten survival. However, whether GOF also occurs with other mutations and whether they are all biologically equal is unknown....
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