Article
MYC phosphorylation at novel regulatory regions suppresses transforming activity.
Cancer research - 1 Nov 2013
Wasylishen Amanda R, Chan-Seng-Yue Michelle, Bros Christina, Dingar Dharmendra, Tu William B, Kalkat Manpreet, Chan Pak-Kei, Mullen Peter J, Huang Ling, Meyer Natalie, Raught Brian, Boutros Paul C, Penn Linda Z
Abstract excerpt
Despite its central role in human cancer, MYC deregulation is insufficient by itself to transform cells. Because inherent mechanisms of neoplastic control prevent precancerous lesions from becoming fully malignant, identifying transforming alleles of MYC that bypass such controls may provide fundamental insights into tumorigenesis. To date, the only activated allele of MYC known is T58A, the study of which led to...
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