Article

Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide <i>Myc</i> Inactivation

2023-02-02

Abstract excerpt

<h4>Summary</h4> MYC proto-oncogene dysregulation alters metabolism, translation and other functions in ways that support tumor induction and maintenance. Although Myc+/- mice are healthier and longer-lived than control mice, the long-term ramifications of more complete Myc loss remain unknown. We now describe the chronic consequences of body-wide Myc inactivation initiated postnatally. “ Myc KO” mice acquire...

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Literature Corpus work: 63e9f699-d7c4-5294-afca-01e68f477712
DOI: 10.1101/2023.01.30.526354

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