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Article

Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.

Nature communications - 3 Apr 2024

Li Jie, Chin Christopher R, Ying Hsia-Yuan, Meydan Cem, Teater Matthew R, Xia Min, Farinha Pedro, Takata Katsuyoshi, Chu Chi-Shuen, Jiang Yiyue, Eagles Jenna, Passerini Verena, Tang Zhanyun, Rivas Martin A, Weigert Oliver, Pugh Trevor J, Chadburn Amy, Steidl Christian, Scott David W, Roeder Robert G, Mason Christopher E, Zappasodi Roberta, Béguelin Wendy, Melnick Ari M

Abstract excerpt

Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploinsufficiency of Crebbp and Kmt2d induces a more severe mouse lymphoma phenotype (vs either allele alone) and unexpectedly confers an immune evasive microenvironment manifesting...

Read the complete abstract on PubMed

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Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to CREB-Binding Protein

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Share to Histone-Lysine N-Methyltransferase

Share to Lymphoma, Large B-Cell, Diffuse

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Source

Open in PubMed Open full text

Identifiers

PMID: 38570506
DOI: 10.1038/s41467-024-47012-1
PMCID: PMC10991284

Genes

CREBBP
KMT2D
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.PMID 38570506Read ↗

Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomasSemantic proximity Read ↗

KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.Semantic proximity Read ↗

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.Semantic proximity Read ↗

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.Semantic proximity Read ↗

Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.Semantic proximity Read ↗

Mutational synergy with <i>CREBBP</i> loss in lymphomagenesis identified through forward insertional mutagenesis in a new DLBCL mouse modelSemantic proximity Read ↗

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.Semantic proximity Read ↗

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