Article

A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins

2020-08-10

Abstract excerpt

<h4>ABSTRACT</h4> The Origin Recognition Complex (ORC), composed of six subunits, ORC1-6, binds to origins of replication as a ring-shaped heterohexameric ATPase that is believed to be essential to recruit and load MCM2-7 around DNA and initiate DNA replication. We had reported the creation of viable cancer cell lines that lacked detectable ORC1 or ORC2 protein without a significant decrease in the number of orig...

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Literature Corpus work: 76ff4109-a4d3-5035-91b0-4e9142e40a38
DOI: 10.1101/2020.08.10.245076

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