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Article

Humanizing the yeast origin recognition complex.

Nature communications - 4 Jan 2021

Lee Clare S K, Cheung Ming Fung, Li Jinsen, Zhao Yongqian, Lam Wai Hei, Ho Vincy, Rohs Remo, Zhai Yuanliang, Leung Danny, Tye Bik-Kwoon

Abstract excerpt

The Origin Recognition Complex (ORC) is an evolutionarily conserved six-subunit protein complex that binds specific sites at many locations to coordinately replicate the entire eukaryote genome. Though highly conserved in structure, ORC's selectivity for replication origins has diverged tremendously between yeasts and humans to adapt to vastly different life cycles. In this work, we demonstrate that the...

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Identifiers

PMID: 33397927
DOI: 10.1038/s41467-020-20277-y
PMCID: PMC7782691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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