Article

A Meier-Gorlin Syndrome Mutation in Orc4 Causes Tissue-Specific DNA Replication Defects in <i>Drosophila melanogaster</i>

2019-07-23

Abstract excerpt

Meier-Gorlin syndrome is a rare recessive disorder characterized by a number of distinct developmental defects, including primordial dwarfism, small ears, and small or missing patella. Genes encoding members of the origin recognition complex (ORC) and additional proteins essential for DNA replication (CDC6, CDT1, GMNN, CDC45, and MCM5) are mutated in individuals diagnosed with MGS. The primary role of ORC is to li...

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Literature Corpus work: 322ad22f-49b4-5d7f-9ce5-c8e5b071e087
DOI: 10.1101/711820

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