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Article

Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation.

The Journal of biological chemistry - 10 Mar 2006

Teer Jamie K, Machida Yuichi J, Labit Helene, Novac Olivia, Hyrien Olivier, Marheineke Kathrin, Zannis-Hadjopoulos Maria, Dutta Anindya

Abstract excerpt

The Origin Recognition Complex (ORC) is a critical component of replication initiation. We have previously reported generation of an Orc2 hypomorph cell line (Delta/-) that expresses very low levels of Orc2 but is viable. We have shown here that Chk2 is phosphorylated, suggesting that DNA damage checkpoint pathways are activated. p53 was inactivated during the derivation of the Orc2 hypomorphic cell lines,...

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Identifiers

PMID: 16407251
DOI: 10.1074/jbc.M507150200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation.PMID 16407251Read ↗

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