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Article

Two subunits of human ORC are dispensable for DNA replication and proliferation

1 Dec 2016

Abstract excerpt

The six-subunit Origin Recognition Complex (ORC) is believed to be an essential eukaryotic ATPase that binds to origins of replication as a ring-shaped heterohexamer to load MCM2-7 and initiate DNA replication. We have discovered that human cell lines in culture proliferate with intact chromosomal origins of replication after disruption of both alleles of ORC2 or of the ATPase subunit, ORC1. The ORC1 or...

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PMID: 27906128
DOI: 10.7554/elife.19084

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