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A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins

28 Sept 2020

Abstract excerpt

The origin recognition complex (ORC), composed of six subunits, ORC1-6, binds to origins of replication as a ring-shaped heterohexameric ATPase that is believed to be essential to recruit and load MCM2-7, the minichromosome maintenance protein complex, around DNA and initiate DNA replication. We previously reported the creation of viable cancer cell lines that lacked detectable ORC1 or ORC2 protein without a...

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PMID: 32989049
DOI: 10.1074/jbc.ra120.015450

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