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Orc6 is a component of the replication fork and enables efficient mismatch repair

27 May 2022

Abstract excerpt

In eukaryotes, the origin recognition complex (ORC) is required for the initiation of DNA replication. The smallest subunit of ORC, Orc6, is essential for prereplication complex (pre-RC) assembly and cell viability in yeast and for cytokinesis in metazoans. However, unlike other ORC components, the role of human Orc6 in replication remains to be resolved. Here, we identify an unexpected role for hOrc6, which is...

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PMID: 35622890
DOI: 10.1073/pnas.2121406119

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