Article

Regulation of epigenetics and chromosome structure by human ORC2

2024-12-21

Abstract excerpt

<h4>SUMMARY</h4> We report a multi-omics study in a human cell line with mutations in three subunits of Origin Recognition Complex (ORC). The ORC subunits bind to DNA independent of each other in addition to as part of a common six-subunit ORC. DNA-bound ORC2 compacts chromatin and attracts repressive histone marks to focal areas of the genome, but ORC2 also activates chromatin at many sites and protects the gene...

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Literature Corpus work: 71edc558-26c8-527a-8c07-5846f3d01603
DOI: 10.1101/2024.12.18.629220

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