Article

The Shu Complex Prevents Mutagenesis and Cytotoxicity of Single-Strand Specific Alkylation Lesions

2021-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans, express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes. It remains an unanswered evolutionary question as to how yeast repairs 3meC, particularly in single-stranded DNA. The yeast Shu complex, a conserved ho...

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Literature Corpus work: 75e9a8df-26e1-5536-9e9b-ad794edc471b
DOI: 10.1101/2021.04.09.439200

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