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Article

A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability.

PLoS genetics - 1 Oct 2013

Kadyrova Lyudmila Y, Mertz Tony M, Zhang Yu, Northam Matthew R, Sheng Ziwei, Lobachev Kirill S, Shcherbakova Polina V, Kadyrov Farid A

Abstract excerpt

Mutations are a major driving force of evolution and genetic disease. In eukaryotes, mutations are produced in the chromatin environment, but the impact of chromatin on mutagenesis is poorly understood. Previous studies have determined that in yeast Saccharomyces cerevisiae, Rtt109-dependent acetylation of histone H3 on K56 is an abundant modification that is introduced in chromatin in S phase and removed by Hst3...

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Identifiers

PMID: 24204308
DOI: 10.1371/journal.pgen.1003899
PMCID: PMC3812082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability.PMID 24204308Read ↗

HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin.Semantic proximity Read ↗

Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins.Semantic proximity Read ↗

Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication.Semantic proximity Read ↗

Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56.Semantic proximity Read ↗

Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.Semantic proximity Read ↗

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A negatively charged residue in place of histone H3K56 supports chromatin assembly factor association but not genotoxic stress resistance.Semantic proximity Read ↗

Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.Semantic proximity Read ↗

Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.Semantic proximity Read ↗

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