Article
A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability.
PLoS genetics - 1 Oct 2013
Kadyrova Lyudmila Y, Mertz Tony M, Zhang Yu, Northam Matthew R, Sheng Ziwei, Lobachev Kirill S, Shcherbakova Polina V, Kadyrov Farid A
Abstract excerpt
Mutations are a major driving force of evolution and genetic disease. In eukaryotes, mutations are produced in the chromatin environment, but the impact of chromatin on mutagenesis is poorly understood. Previous studies have determined that in yeast Saccharomyces cerevisiae, Rtt109-dependent acetylation of histone H3 on K56 is an abundant modification that is introduced in chromatin in S phase and removed by Hst3...
Topics
- Acetylation
- Chromatin
- Chromosome Aberrations
- DNA Mismatch Repair
- DNA Replication
- DNA-Directed DNA Polymerase
- Genomic Instability
- Histone Deacetylases
- Histones
- Mutation