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Article

The Shu complex interacts with the replicative helicase to prevent mutations and aberrant recombination.

The EMBO journal - 1 Mar 2025

Fagunloye Adeola A, De Magis Alessio, Little Jordan H, Contreras Isabela, Dorwart Tanis J, Bonilla Braulio, Gupta Kushol, Clark Nathan, Zacheja Theresa, Paeschke Katrin, Bernstein Kara A

Abstract excerpt

Homologous recombination (HR) is important for DNA damage tolerance during replication. The yeast Shu complex, a conserved homologous recombination factor, prevents replication-associated mutagenesis. Here we examine how yeast cells require the Shu complex for coping with MMS-induced lesions during DNA replication. We find that Csm2, a subunit of the Shu complex, binds to autonomous-replicating sequences (ARS) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39838174
DOI: 10.1038/s44318-025-00365-9
PMCID: PMC11876325

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