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Genome Profiling for Aflatoxin B1 Resistance in <i>Saccharomyces cerevisiae</i> Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B <sub>1</sub> -associated DNA Damage

2019-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Exposure to the mycotoxin aflatoxin B1 (AFB 1 ) strongly correlates with hepatocellular carcinoma. P450 enzymes convert AFB 1 into a highly reactive epoxide that forms unstable 8,9-dihydro-8-( N 7-guanyl)-9-hydroxyaflatoxin B1 (AFB 1 - N 7 -Gua) DNA adducts, which convert to stable mutagenic AFB 1 formamidopyrimidine (FAPY) DNA adducts. In CYP1A2-expressing budding yeast, AFB 1 is a weak...

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Literature Corpus work
e417c480-5cc0-563e-8a1e-4507de9c5625
DOI
10.1101/629436
Open publication

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Genome Profiling for Aflatoxin B1 Resistance in <i>Saccharomyces cerevisiae</i> Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B <sub>1</sub> -associated DNA DamageDOI 10.1101/629436
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