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Article

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects.

Nature communications - 11 Sept 2018

Srivatsan Anjana, Li Bin-Zhong, Szakal Barnabas, Branzei Dana, Putnam Christopher D, Kolodner Richard D

Abstract excerpt

Genome instability is associated with tumorigenesis. Here, we identify a role for the histone Htz1, which is deposited by the Swr1 chromatin-remodeling complex (SWR-C), in preventing genome instability in the absence of the replication fork/replication checkpoint proteins Mrc1, Csm3, or Tof1. When combined with deletion of SWR1 or HTZ1, deletion of MRC1, CSM3, or TOF1 or a replication-defective mrc1 mutation...

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Identifiers

PMID: 30206225
DOI: 10.1038/s41467-018-06131-2
PMCID: PMC6134005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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