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The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA

2024-02-15

Abstract excerpt

Templated DNA repair that occurs during homologous recombination and replication stress relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs. The Shu complex is a RAD51 paralog-containing complex consisting of SWSAP1 and SWS1. We demonstrate that SWSAP1-SWS1 binds RAD51, maintains RAD51 filament stability, and enables strand exchange. Using single molecule confocal fluorescence m...

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Identifiers and source

Literature Corpus work
75abb435-0912-53d2-b24b-d1a8a1e945d6
DOI
10.1101/2024.02.14.580393
Open publication

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The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNADOI 10.1101/2024.02.14.580393
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