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Telomeric amplicons of <i>SUL1</i> and Y’ in yeast are generated by microhomology-mediated break induced replication occurring <i>in cis</i>

2026-04-09

Abstract excerpt

<h4>ABSTRACT</h4> Gene amplification is a potent driver of evolution and is thought to contribute to genetic diseases, including cancer. The yeast Saccharomyces cerevisiae is a powerful organism for understanding amplification mechanisms. When yeast is grown long term in sulfate-limiting chemostats, amplification of the gene that encodes the primary sulfate transporter, SUL1 , is a common outcome. Here we descr...

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Literature Corpus work
154d37d1-6259-5dcd-be11-a53a934bd93f
DOI
10.64898/2026.04.07.716220
Open publication

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Telomeric amplicons of <i>SUL1</i> and Y’ in yeast are generated by microhomology-mediated break induced replication occurring <i>in cis</i>DOI 10.64898/2026.04.07.716220
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