Article

Major functional bias for mitochondrial complexes in genome-wide CRISPR screens

2020-08-31

Abstract excerpt

We present FLEX ( F unctiona l e valuation of e x perimental perturbations), a pipeline that leverages several functional annotation resources to establish reference standards for benchmarking human genome-wide CRISPR screen data and methods for analyzing them. We apply FLEX to analyze data from the diverse cell line screens generated by the DepMap project. We identify a dominant mitochondria-associated signal,...

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Literature Corpus work: 75af843b-d96f-529d-9c3e-34d7d28b28c0
DOI: 10.1101/2020.08.31.273730

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