Article

Time-resolved mitochondrial-focused screening identifies regulatory components of oxidative metabolism

2024-06-19

Abstract excerpt

<h4>SUMMARY</h4> Defects in mitochondrial oxidative metabolism contribute to various genetic inherited disorders, termed mitochondrial diseases, with limited treatment options. Given the lack of functional annotation for numerous mitochondrial proteins, there is a necessity for an extensive gene inventory related to mitochondrial function, with special interest in Oxidative Phosphorylation (OXPHOS). To address th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01b490c3-f4b3-5e78-bc88-e25dbb61dbb3
DOI: 10.1101/2024.06.19.599690

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Time-resolved mitochondrial-focused screening identifies regulatory components of oxidative metabolismDOI 10.1101/2024.06.19.599690Read

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.Semantic proximity Read

Exercise based Intervention For Metabolic Inflexibility Linked With Lipid Storage Myopathy Using Innovative CRISPR <i>Etf-QO</i> Mutant Knock-in ModelsSemantic proximity Read

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s diseaseSemantic proximity Read

Mitochondrial medicine in the omics era.Semantic proximity Read

Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy productionSemantic proximity Read

An ATF4-centric regulatory network is required for the assembly and function of the OXPHOS systemSemantic proximity Read

Mitochondrial energy generation disorders: genes, mechanisms, and clues to pathology.Semantic proximity Read

Interaction and regulation of the mitochondrial proteome – in health and diseaseSemantic proximity Read

The Disease Gene THAP12 is a Transcriptional Regulator of Mitochondrial ETC Complex ISemantic proximity Read

C6orf203 controls OXPHOS function through modulation of mitochondrial protein biosynthesisSemantic proximity Read

Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I.Semantic proximity Read

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.Semantic proximity Read