Article

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

2024-01-14

Abstract excerpt

Pooled CRISPR-Cas9 genetic knockout screens are powerful high-throughput tools for identifying chemo-genetic, synthetic-lethal and synthetic-viability interactions and are used as a key step towards identifying disease-modifying knockout candidates and informing drug design and therapeutic regimens. CRISPR guide libraries are commercially available for purchase and have been widely applied in different cell lines....

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Literature Corpus work: ae84c8e3-3b61-53fa-9762-05098251d35f
DOI: 10.1101/2024.01.14.575203

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