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Article

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.

Cell metabolism - 13 Dec 2016

Arroyo Jason D, Jourdain Alexis A, Calvo Sarah E, Ballarano Carmine A, Doench John G, Root David E, Mootha Vamsi K

Abstract excerpt

Oxidative phosphorylation (OXPHOS) is the major pathway for ATP production in humans. Deficiencies in OXPHOS can arise from mutations in either mitochondrial or nuclear genomes and comprise the largest collection of inborn errors of metabolism. At present we lack a complete catalog of human genes and pathways essential for OXPHOS. Here we introduce a genome-wide CRISPR "death screen" that actively selects dying...

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Source

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Identifiers

PMID: 27667664
DOI: 10.1016/j.cmet.2016.08.017
PMCID: PMC5474757

Genes

FASTKD2
NGRN
RPUSD3
RPUSD4
TRUB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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