Article

Genome mutations and environmental perturbations reshape the epigenomic topology to drive functional collapse in digital cells

2026-08-25

Abstract excerpt

Understanding how genetic and environmental perturbations drive cellular dysfunction remains a challenge. Using digital somatic cells, we evaluate the functionality of over eight thousand genomes across thousands of environments alongside systematic mutational screens. We find that environmental perturbations induce loss of function with a higher probability than point mutations. Crucially, however, most mutations...

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Identifiers and source

Literature Corpus work: f6a17125-72e2-5d9c-86ae-70b70478f864
DOI: 10.64898/2026.08.24.746697

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