Article

The Disease Gene THAP12 is a Transcriptional Regulator of Mitochondrial ETC Complex I

2026-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Complex I (CI) is the largest and most disease-associated component of the mitochondrial electron transport chain. While many diseases are linked to defects in specific CI subunits, the extent to which non-mitochondrial proteins contribute to CI function or disease is less clear. Here, we perform genome-wide CRISPR screens to identify regulators of CI abundance across its N, Q, and P modules, wh...

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Literature Corpus work: c9ca4b70-6594-5351-827a-fe01ed853746
DOI: 10.64898/2026.07.16.738975

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