Article

Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice

2022-02-11

Abstract excerpt

The ε4 variant of apolipoprotein E ( APOE ) is the strongest and most common genetic risk factor for Alzheimer’s disease (AD). While the mechanism of conveyed risk is incompletely understood, promotion of inflammation, dysregulated metabolism, and protein misfolding and aggregation are contributors to accelerating disease. Here we determined the concurrent effects of systemic metabolic changes and brain inflammat...

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Literature Corpus work: 74a847ca-298e-5b25-9a6f-71c017d36eac
DOI: 10.1101/2022.02.11.480074

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