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Article

Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice.

Neurobiology of aging - 1 Mar 2023

Fleeman Rebecca M, Snyder Amanda M, Kuhn Madison K, Chan Dennis C, Smith Grace C, Crowley Nicole A, Arnold Amy C, Proctor Elizabeth A

Abstract excerpt

The ε4 variant of apolipoprotein E (APOE) is the strongest and most common genetic risk factor for Alzheimer's disease (AD). While the mechanism of conveyed risk is incompletely understood, promotion of inflammation, dysregulated metabolism, and protein misfolding and aggregation are contributors to accelerating disease. Here we determined the concurrent effects of systemic metabolic changes and brain...

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Identifiers

PMID: 36572594
DOI: 10.1016/j.neurobiolaging.2022.11.015
PMCID: PMC9892258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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