Article

Network-Level Organization of Systemic Inflammation Reflects Early Alzheimer’s-Like Behavioral Changes

2025-10-14

Abstract excerpt

<title>Abstract</title> <p>Systemic immune alterations are increasingly recognized as features of Alzheimer’s disease (AD), yet their network-level organization in preclinical models is poorly understood. We profiled 66 circulating cytokines and growth factors in young adult TgF344-AD and wild-type rats, reduced the data into five inflammatory profiles via principal component analysis, and mapped these profiles o...

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Literature Corpus work: e031a80e-157c-59a7-a3e8-581c4cda8488
DOI: 10.21203/rs.3.rs-7482654/v1

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