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Proteomic and metabolic profiling reveals <i>APOE4</i> -dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysis

2025-06-16

Abstract excerpt

Apolipoprotein E ( APOE ) genetic variation is the strongest genetic risk factor for late onset Alzheimer’s disease (LOAD). Studies on APOE genotype dependent changes have largely focused on amyloid beta (Aβ) aggregation, disease pathology, and lipid metabolism. Recently, there has been increased interest in the relationship between metabolic function and APOE genetic variation. In this study, we examined how...

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Literature Corpus work
fb3ba2ca-2eea-5edf-95f8-b95b3a3e9c61
DOI
10.1101/2025.06.15.659811
Open publication

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Proteomic and metabolic profiling reveals <i>APOE4</i> -dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysisDOI 10.1101/2025.06.15.659811
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