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Generation of iPSC lines with high cytogenetic stability from peripheral blood mononuclear cells (PBMCs)

2021-09-28

Abstract excerpt

<h4>SUMMARY</h4> The utility of human induced pluripotent stem cells (hiPSCs) is contingent upon genomic integrity and stability. Recurrent genomic aberrations have been observed in human iPSC lines upon long-term culture, ∼10-25% demonstrate karyotype abnormalities. We describe a new and reliable non-integrating episomal plasmid reprogramming method for fresh (unexpanded) peripheral blood mononuclear cells (PBMC...

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Literature Corpus work
33c4458b-7aea-5689-ad20-b4441924ee4b
DOI
10.1101/2021.09.27.462082
Open publication

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Generation of iPSC lines with high cytogenetic stability from peripheral blood mononuclear cells (PBMCs)DOI 10.1101/2021.09.27.462082
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