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Article

Dual roles for piRNAs in promoting and preventing gene silencing in C. elegans.

Cell reports - 7 Dec 2021

Montgomery Brooke E, Vijayasarathy Tarah, Marks Taylor N, Cialek Charlotte A, Reed Kailee J, Montgomery Taiowa A

Abstract excerpt

Piwi-interacting RNAs (piRNAs) regulate many biological processes through mechanisms that are not fully understood. In Caenorhabditis elegans, piRNAs intersect the endogenous RNA interference (RNAi) pathway, involving a distinct class of small RNAs called 22G-RNAs, to regulate gene expression in the germline. In the absence of piRNAs, 22G-RNA production from many genes is reduced, pointing to a role for piRNAs in...

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Identifiers

PMID: 34879267
DOI: 10.1016/j.celrep.2021.110101
PMCID: PMC8730336

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