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Article

Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.

Molecular cell - 23 Oct 2009

Gu Weifeng, Shirayama Masaki, Conte Darryl, Vasale Jessica, Batista Pedro J, Claycomb Julie M, Moresco James J, Youngman Elaine M, Keys Jennifer, Stoltz Matthew J, Chen Chun-Chieh G, Chaves Daniel A, Duan Shenghua, Kasschau Kristin D, Fahlgren Noah, Yates John R, Mitani Shohei, Carrington James C, Mello Craig C

Abstract excerpt

Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate sequence-specific regulation of diverse biological processes. Here, we combine deep-sequencing and genetic approaches to explore the biogenesis and function of endo-siRNAs in C. elegans. We describe conditional alleles of the Dicer-related helicase, drh-3, that abrogate both RNA interference and the biogenesis of endo-siRNAs,...

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Source

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Identifiers

PMID: 19800275
DOI: 10.1016/j.molcel.2009.09.020
PMCID: PMC2776052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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