Article

The Ubiquitin-Proteasome Pathway Mediates Selective Degradation of Unloaded Argonautes in <i>C. elegans</i>

2025-09-12

Abstract excerpt

Argonaute proteins are essential effectors of small RNA-mediated gene regulation, yet the extent to which their stability depends on small RNA loading remains poorly understood. In Caenorhabditis elegans , we systematically disrupted the small RNA binding capacity of multiple Argonaute proteins to assess their stability in the absence of small RNA partners. We found that while most Argonautes remain stable when u...

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Literature Corpus work: fc7b58a0-9b0e-5914-a6f3-06dfe3c9fdfa
DOI: 10.1101/2025.09.10.675458

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