Article

A wave of WNT signalling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells

2018-10-10

Abstract excerpt

Long range signalling by morphogens and their inhibitors define embryonic patterning yet quantitative data and models are rare, especially in humans. Here we use a human embryonic stem cell “gastruloid” system to model formation of the primitive streak (PS) by WNT. In the pluripotent state E-CADHERIN (E-CAD) transduces boundary forces to focus WNT signalling to colony border. Following application of WNT ligand, E...

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Literature Corpus work: 740ee30d-a96f-5f84-8a29-0a92e70f50fa
DOI: 10.1101/440602

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