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Article

Boundary constraints can determine pattern emergence

2025-07-22

Abstract excerpt

<h4>SUMMARY</h4> The robust patterning of cell fates during embryonic development requires precise coordination of signalling gradients within defined spatial constraints. Using a geometrically confined in vitro system derived from human embryonic stem cells, we demonstrate that patterning of neuromesodermal progenitors (NMPs) during axial elongation is driven by boundary-dependent mechanisms. Despite extensive...

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Identifiers and source

Literature Corpus work
98c14580-06ae-54f8-aae6-83a7ea4fbafc
DOI
10.1101/2025.07.21.665949
Open publication

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Boundary constraints can determine pattern emergenceDOI 10.1101/2025.07.21.665949
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