Article

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids

2018-10-10

Abstract excerpt

During gastrulation, the pluripotent epiblast is patterned into the three germ layers, which form the embryo proper. This patterning requires a signaling cascade involving the BMP, WNT and NODAL pathways; however, how these pathways regulate one another in space and time to generate cell-fate patterns remains unknown. Using a human gastruloid model, we show that BMP signaling initiates a wave of WNT signaling, whi...

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Identifiers and source

Literature Corpus work: 7e4a020f-bdac-5575-ac82-501cb3dacaa6
DOI: 10.1101/440164

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