Article
Epithelial cell plasticity drives endoderm formation during gastrulation.
Nature cell biology - 1 Jul 2021
Scheibner Katharina, Schirge Silvia, Burtscher Ingo, Büttner Maren, Sterr Michael, Yang Dapeng, Böttcher Anika, Ansarullah, Irmler Martin, Beckers Johannes, Cernilogar Filippo M, Schotta Gunnar, Theis Fabian J, Lickert Heiko
Abstract excerpt
It is generally accepted that epiblast cells ingress into the primitive streak by epithelial-to-mesenchymal transition (EMT) to give rise to the mesoderm; however, it is less clear how the endoderm acquires an epithelial fate. Here, we used embryonic stem cell and mouse embryo knock-in reporter systems to combine time-resolved lineage labelling with high-resolution single-cell transcriptomics. This allowed us to...
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