Article

Dependence of cell fate potential and cadherin switching on primitive streak coordinate during differentiation of human pluripotent stem cells

2025-02-01

Abstract excerpt

During gastrulation, the primitive streak (PS) forms and begins to differentiate into mesendodermal subtypes. This process involves an epithelial-mesenchymal transition (EMT), which is marked by cadherin switching, where E-Cadherin is downregulated, and N-Cadherin is upregulated. To understand the relationships between differentiation, EMT, and cadherin switching, we made measurements of these processes during dif...

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Literature Corpus work: ada2964a-fcdf-5c53-9f9a-c7b9fa05e0d9
DOI: 10.1101/2025.01.31.635963

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